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dc.contributor.authorGuellil, Meriam
dc.contributor.authorKersten, Oliver
dc.contributor.authorNamouchi, Amine
dc.contributor.authorBauer, Egil Lindhart
dc.contributor.authorDerrick, Michael
dc.contributor.authorJensen, Anne Østergaard
dc.contributor.authorStenseth, Nils Christian
dc.contributor.authorBramanti, Barbara
dc.date.accessioned2019-01-22T14:03:00Z
dc.date.available2019-01-22T14:03:00Z
dc.date.created2018-09-28T14:17:10Z
dc.date.issued2018
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. 2018, 115 (41), 10422-10427.nb_NO
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/11250/2581821
dc.description.abstractLouse-borne relapsing fever (LBRF) is known to have killed millions of people over the course of European history and remains a major cause of mortality in parts of the world. Its pathogen, Borrelia recurrentis, shares a common vector with global killers such as typhus and plague and is known for its involvement in devastating historical epidemics such as the Irish potato famine. Here, we describe a European and historical genome of B. recurrentis, recovered from a 15th century skeleton from Oslo. Our distinct European lineage has a discrete genomic makeup, displaying an ancestral oppA1 gene and gene loss in antigenic variation sites. Our results illustrate the potential of ancient DNA research to elucidate dynamics of reductive evolution in a specialized human pathogen and to uncover aspects of human health usually invisible to the archaeological record.nb_NO
dc.language.isoengnb_NO
dc.publisherNational Academy of Sciencesnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.subjectancient genomicsnb_NO
dc.subjectrelapsing fevernb_NO
dc.subjectvector-borne pathogennb_NO
dc.subjectimmune evasionnb_NO
dc.subjectancient DNAnb_NO
dc.subjectaDNAnb_NO
dc.titleGenomic blueprint of a relapsing fever pathogen in 15th century Scandinavianb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holderCopyright © 2018 the Author(s). Published by PNAS.nb_NO
dc.source.pagenumber10422-10427nb_NO
dc.source.volume115nb_NO
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americanb_NO
dc.source.issue41nb_NO
dc.identifier.doi10.1073/pnas.1807266115
dc.identifier.cristin1615797
cristin.unitcode7530,43,0,0
cristin.unitnameArkeologiavdelingen
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal